The atomization characteristics of 4 handheld sprayers (Leco P-1, Colt ULV Aerosol Generator, ULVAFAN MK2, Turbair ElectraFan 12) and a Stihl SR400 backpack sprayer were evaluated with the use of water- and oil-based solutions. The effects on droplet-size spectrum (i.e., droplet size) for 3 insecticides (Tempo SC Ultra®, Anvil 10 10®, and Aqua-Reslin®) were also evaluated. Generic solutions were used to simulate the physical properties of the active-ingredient solutions in some tests. Significant differences were observed in the droplet spectrum generated by the different sprayers. The volume median diameter of the equipment tested ranged from 14.9 to 90.5 µm for the water-based solutions and from 11.7 to 92.4 µm for the oil-based solutions. The Colt ULV sprayer was the only one tested that complied with label requirements for aerosols, yielding acceptable D_V0.5 values of 14.9–16.0 µm with water-based Aqua-Reslin and 14.1 µm with Anvil 10 10. The information presented will allow equipment operators to make an informed decision when selecting equipment and operational parameters.